For tackling cystic acne, topical antibiotics like erythromycin and clindamycin are often used for their anti-inflammatory and antibacterial properties. To enhance their effectiveness and reduce the risk of bacterial resistance, they’re commonly paired with benzoyl peroxide, available in wash-off and leave-on forms.

Using topical antibiotics alone isn’t recommended due to the potential for antibiotic resistance. That’s why combination treatments are popular; they’re not only more effective but also improve patient adherence to the regimen.

Side effects are generally rare, but there have been isolated cases of digestive issues when using topical clindamycin. However, the overall risk is considered low.

While effective for mild to moderate acne, there’s growing concern about the decreasing sensitivity of acne-causing bacteria like P. acnes to these antibiotics, which could limit their future usefulness.